Endocrine Abstracts

Background: Lenvatinib is an oral chemotherapy for metastatic radioiodine-refractory differentiated thyroid cancer (RRDTC) which significantly improves progression free survival (PFS). It has been proved that higher rates of dose interruption or reduction of Lenvatinib have a negative impact on PFS. Patients with active cancer, such as RRDTC, have an increased risk of contracting Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) and developing complications, especial...

Background: Cell membrane fluidity of erythrocytes in patients with type 2 diabetes can be influenced by glycosylation processes, changes in lipid homeostasis and oxidative stress.Objectives: We have measured red blood cell membrane fluidity looking for differences between healthy people and diabetic subjects and also between diabetic patients affected by macroangiopathy (vascular diabetic foot) and not.Methods: We have enrolled 32...

Medullary thyroid carcinoma (MTC) accounts for 1%–2% of thyroid cancers and has a variable clinical course. MTCs present with locoregional metastasis in 50% of patients and distant metastasis in 10% to 15% at the time of initial diagnosis. The lungs, liver, and bone are common metastatic sites, and distant metastasis is known to be a poor prognostic factor for long-term oncologic outcomes. We present the long course case, under somatostatin analogues (SSA) therapy, of a 7...

Introduction: Non-functioning (NF), sporadic and MEN1 associated, G1-G2 pancreatic neuroendocrine tumors (PanNETs) usually display an indolent course. Surgery is the first-choice treatment for localized tumors >2 cm. Unresectable or metastatic PanNETs expressing somatostatin receptors (SSTRs) are treated with somatostatin analogs (SSAs). The standard treatment for patients with PanNETs ≤ 2 cm is active surveillance (AS). Yet no evidence of the value of SSA treatment ...

Introduction: Infundibulo-neurohypophysitis (INH) is an uncommon inflammatory disorder. Because of the location of inflammation, it selectively affects the neuropituitary and pituitary stalk. The differential diagnosis remains often challenging with neoplastic lesions, such as germ cell neoplasia, Langerhans cell histiocytosis, Erdheim-Chester Disease, metastasis. Our clinical case is emblematic for pitfalls in diagnosis of the pituitary stalk lesionCase...